Dr Shamanthi Jayasooriya


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Shami is a NIHR Academic Clinical lecturer in primary care medicine and a General Practitioner based at Page Hall Medical Centre, a Deep End Clinical Research Cluster practice, in one of the most deprived and ethnically diverse areas of Sheffield.  She has spent several years working at the Medical Research Council Unit in The Gambia. She was awarded a Medical Research Council (MRC) PhD Scholarship (2007-2011) under the supervision of Professor Hilton Whittle (LSHTM) and Professor Alan Rickinson (Birmingham) to study immune responses to Epstein-Barr Virus in children in Sub-Saharan. Subsequently, she returned to MRC The Gambia (2017-2018) and was primary study clinician on Tb Sequel, a multi-centre study exploring lung impairment post Tuberculosis infection. 

Shami has research interests that centre around global Lung Health, with a focus on health implementation research around service provision for patients with Non-Communicable Chronic Lung Disease in Lower- and Middle- Income countries (LMICs). She is also involved as a research associate with the NIHR Global Health Research Group on Preterm Birth Intervention and Management (PRIME).  

 

Publications: 

S.Jayasooriya, A Jobe, S Badjie, O Owolabi, A Rachow, J Sutherland, B Kampmann. The burden of non-TB lung disease presenting to TB clinics in The Gambia: preliminary data in the Xpert MTB/Rif era. Public Health Action 2019 9(4) 21 Dec 2019

JH Chertow, MS Alkaitis, G Nardone, AK. Ikeda, AJ Cunnington, J Okebe, AO Ebonyi, M Njie, S Correa, S Jayasooriya, C Casals-Pascual, O Billker, DJ Conway, M Walther, H Ackerman.Plasmodium infection is associated with impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/ Substrate Homeostasis. Plos Pathog 2015.1(9):e1005119

S Jayasooriya, TI de Silva, J Njie-jobe, C Sanyang, AM Leese, AI Bell, KA McAulay, P Yanchun, HM Long, T Dong, HC Whittle, AB Rickinson, SL Rowland-Jones, AD Hislop, KL Flanagan.Early virological and immunological events in asymptomatic Epstein-Barr virus infection in African children. PLoS Pathog. 2015 Mar 27;11(3):e1004746

S Jayasooriya, A Hislop, Y Peng, D Croom-Carter, Y Jankey, A Bell, T Dong, S Rowland-Jones, A Rickinson, M Walther, H Whittle. Revisiting the effect of acute P. falciparum malaria on Epstein-Barr virus: host balance in the setting of reduced malaria endemicity. PLoS One 2012;7(2):e31142

M Walther, D Jeffries, OC Finney, M Njie, A Ebonyi, S Deininger, E Lawrence, A Ngwa-Amambua, S Jayasooriya, IH Cheeseman, N Gomez-Escobar, J Okebe, DJ Conway, EM Riley.Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria. PLoS Pathog 2009 Apr;5(4):e1000354